Table 2.
Interaction between rs7903146 and rs10830963 (as continuous and categorical variable) and levels of SSB categories intake on log-fasting glucose.
| rsID | Gen | Genotype | SSB Category 2 | SSB Category 3 | SSB Category 4 | Pi | |||
|---|---|---|---|---|---|---|---|---|---|
| Β (SE) | Pt | Β (SE) | Pt | Β (SE) | Pt | ||||
| rs7903146 | TCF7L2 | 0,1,2 | 0.0004 (0.01) | 0.97 | 0.020 (0.01) | 0.11 | 0.05 (0.01) | 0.001 | 0.002 |
| C/C | 4.37 (0.053) | 0.32 | 4.20 (0.06) | 0.44 | 4.33 (0.072) | 0.80 | 0.005 | ||
| C/T | −0.006 (0.02) | 0.10 | 0.03 (0.02) | 0.10 | 0.03 (0.02) | 0.09 | |||
| T/T | 0.009 (0.03) | 0.77 | 0.02 (0.03) | 0.53 | 0.14 (0.04) | 0.0006 | |||
| rs10830963 | MTNR1B | 0,1,2 | 0.005 (0.01) | 0.67 | 0.01 (0.01) | 0.43 | 0.013 (0.01) | 0.47 | 0.83 |
| C/C | 4.21 (0.053) | 0.26 | 4.30 (0.058) | 0.61 | 4.28 (0.072) | 0.88 | 0.001 | ||
| C/G | 0.01 (0.02) | 0.54 | 0.01 (0.02) | 0.41 | −0.03 (0.02) | 0.16 | |||
| G/G | −0.004 (0.04) | 0.91 | 0.01 (0.05) | 0.75 | 0.19 (0.05) | 0.0008 | |||
β: intercept of the reference (first) genotype or regression coefficient for number of risk alleles and for non-reference genotypes when treated as a categorical variable, SE: standard error, Pt: p value for trend, Pi: p value for interaction. Model adjusted for: age, sex, BMI, waist circumference, physical activity, education, socio-economic level, smoking, consumptions: fruit, vegetables, sugar, processed meats, alcoholic beverages and % Amerindian ancestry, p values in bold are significant after Bonferroni correction (p < 0.0031), n = 2828.