Table 5.
Area under the curve (AUC) and concentration max (CMax) for berberine, insulin, and glucose.
| Berberine | AUC (ng/mL × 120 min) |
CMax (ng/mL) |
|---|---|---|
| PLA | 20.2 ± 16.2 | 0.22 ± 0.18 |
| B500 | 42.3 ± 17.6 | 0.40 ± 0.17 |
| D100 | 284.2 ± 115.9 | 3.8 ± 1.4 |
| D200 | 929 ± 694 | 12.0 ± 10.1 |
| p | 0.045 | 0.06 |
| Insulin |
AUC
(μIU/mL × 120 min) |
CMax
(μIU/mL) |
| PLA | 8260 ± 420 | 110.6 ± 24.3 |
| B500 | 7429 ± 1519 | 99.1 ± 6.6 |
| D100 | 8502 ± 717 | 107.2 ± 21.4 |
| D200 | 7242 ± 1263 | 98.1 ± 3.4 |
| p | 0.22 | 0.36 |
| Glucose |
AUC
(mg/dL × 120 min) |
CMax
(mg/dL) |
| PLA | 12,199 ± 1602 | 146.2 ± 13.9 |
| B500 | 12,029 ± 194 | 139.4 ± 32.8 |
| D100 | 12,381 ± 1128 | 140.8 ± 8.8 |
| D200 | 11,898 ± 2058 | 139.0 ± 16.6 |
| p | 0.92 | 0.77 |