Scheme 2.
Synthesis of azoles 6–9. Reagents and conditions: (a) 2-PrOH, 2,4-PD (dropwise), HCl, Δ, 9 h, 74%; (b) 2-PrOH, 2,5-HD (dropwise), AcOH, Δ, 3 h, 80%; (c) MeOH, PhNCS (dropwise), Δ, 2 h, H2O, 93%; (d) 4% NaOH, Δ, 3 h, AcOH to pH 6, 83%.
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