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. 2021 Dec 26;27(1):123. doi: 10.3390/molecules27010123

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Apoptosis/necrosis assessment in HT-29 (a) and HepG-2 (b) cells after exposure to the synthesized compounds. Cells were exposed to predetermined IC₅₀ of compounds 5, 7a, 8, and 9b for 24 h and were stained with annexin V-FITC/PI. Cell populations were plotted as percentage of total events. Data is presented as mean ± SD; n = 3. * Significantly different from the control group at p < 0.05. ** Significantly different from the control group at p < 0.005 **** Significantly different from the control group at p < 0.0001.