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. 2021 Dec 29;27(1):194. doi: 10.3390/molecules27010194

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of Pj-EE and four different solvent fractions on the carrageenan-induced acute paw edema mouse model. (a) Schematic of carrageenan-induced acute paw edema experiment. The ICR mice were orally treated with 100 μL of different solutions based on different groups for 10 days: a normal group (0.5% carboxymethylcellulose (CMC)) or carrageenan group as a control group (0.5% CMC), treatment groups (100 mg/kg Pj-EE, Pj-EE-HF, Pj-EE-CF, Pj-EE-BF, or Pj-EE-WF). Acute paw edema was triggered by an intraplantar injection of 1% carrageenan (100 μL/mouse) and mice were sacrificed after 3 h. (b) A representative photograph of paw inflammatory symptoms. (c–e) The severity of paw edema was evaluated by measuring the weight (c), thickness (d), and volume (e) of each paw of mouse. Results are expressed as mean ± standard deviation (n = 12). ^## p < 0.01 compared to normal group, and * p < 0.05 and ** p < 0.01 compared to control group (carrageenan alone). The p-value was analyzed using one-way ANOVA.

Effects of Pj-EE and four different solvent fractions on the carrageenan-induced acute paw edema mouse model. (a) Schematic of carrageenan-induced acute paw edema experiment. The ICR mice were orally treated with 100 μL of different solutions based on different groups for 10 days: a normal group (0.5% carboxymethylcellulose (CMC)) or carrageenan group as a control group (0.5% CMC), treatment groups (100 mg/kg Pj-EE, Pj-EE-HF, Pj-EE-CF, Pj-EE-BF, or Pj-EE-WF). Acute paw edema was triggered by an intraplantar injection of 1% carrageenan (100 μL/mouse) and mice were sacrificed after 3 h. (b) A representative photograph of paw inflammatory symptoms. (c–e) The severity of paw edema was evaluated by measuring the weight (c), thickness (d), and volume (e) of each paw of mouse. Results are expressed as mean ± standard deviation (n = 12). ^## p < 0.01 compared to normal group, and * p < 0.05 and ** p < 0.01 compared to control group (carrageenan alone). The p-value was analyzed using one-way ANOVA.