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. 2021 Dec 21;27(1):19. doi: 10.3390/molecules27010019

Scheme 2.

Scheme 2

Synthesis of (1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-[3-(1-methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-yl]-methanones (6a–f). Reagents and conditions: (i) oxalyl chloride, diethyl ether, r.t., overnight, then −65 °C, sodium methoxide solution 25 wt. % in methanol, r.t., 2 h, 62–73%; (ii) dimethylsulfoxide, r.t., 30 min. 60–85%.