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. 2021 Nov 8;145(2):134–150. doi: 10.1161/CIRCULATIONAHA.121.057709

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Genome-wide association studies and gene prioritization. A and B, Manhattan plots visualizing the genome-wide association results for retinal vascular fractal dimension (FD; A) and density (B), which identify 7 and 13 loci, respectively. Gene prioritization with the Polygenic Priority Score (PoPS) method.⁶⁷ C and D, Prioritized genes at each locus (see locus-specific prioritizations in Figure S15). The locus-specific genes prioritized by PoPS at each locus are labeled in A and B. The x axes in C and D are arbitrary and reflect the ordered genes by PoPS score.