Table 1.
A selection of the most used diversity indices and measures, showing an unchanged or lower microbial diversity in depressed individuals.
| Source | Shannon | Ace | Chao1 | Nr. OTUs | UniFrac | PLS-DA |
|---|---|---|---|---|---|---|
| [41] | D = | D sign. | ||||
| [42] | aMDD ↑, rMDD = | MDD = | MDD = | MDD = | ||
| [43] | MDD = | |||||
| [44] | MDD = | MDD = | ||||
| [46] | BD ↓, MDD = | BD ↓, MDD = | BD, MDD, C sign. | |||
| [47] | P = | P = | ||||
| [48] | P ↓ | P ↓ | ||||
| [49] | MDD = | MDD = | MDD sign. | |||
| [50] | MDD =, BD = | MDD ↓, BD = | ||||
| [51] | MDD = | MDD = | MDD = | MDD sign. | ||
| [52] | BD = | BD = | BD = | BD = | ||
| [53] | D = | D ↓ | D = | |||
| [54] | BD ↓ * | BD ↓ * | BD sign. | |||
| [55] | D = IBS | D = IBS | D, IBS sign. | |||
| [56] | IBS ↓ | IBS sign. | ||||
| [57] | MDD = | MDD = | MDD sign. | |||
| [58] | MDD ↓ | MDD ↓ | MDD ↓ | MDD sign. | ||
| [59] | pm = | |||||
| [60] | D ↓, IBS ↓ | |||||
| [61] | D ↓ | D ↓ | ||||
| [62] | MDD sign. | |||||
| [63] | MDD = | MDD sign. | ||||
| [64] | BD = | BD = | BD sign. | |||
| [65] | BD = | BD sign. |
“UniFrac” includes weighted and/or unweighted UniFrac distances. “↓” shows a significantly reduced diversity in diseased subjects compared to controls or an inverse correlation with more severe symptoms, while “↑” indicates a significantly increased diversity or a positive correlation with more severe symptoms. “=” demonstrates no significant difference, while “sign.” shows a significant difference. Empty cells symbolize that no results were reported. Abbreviations: MDD, major depressive disorder; BD, bipolar disorder; C, control group; P, psychiatric subjects; D, depression in general; IBS, irritable bowel syndrome; a, active disease group; r, response group; pm, psychiatric measures; OTU, operational taxonomic unit; *, only showing a trend, due to small sample size.