Skip to main content
. 2021 Dec 30;27(1):211. doi: 10.3390/molecules27010211

Table 1.

Functional implications of miRNAs in the development and progression of bone diseases.

Bone Disease miRNA miRNA Regulation Target Biological Implication Reference
Osteoporosis miR-148a Upregulated ER-α Inhibition of osteoblast cell growth and osteoblast apoptosis [49]
miR-122-5p Downregulated ER-α Development of osteoporosis [50]
miR-144-3p Downregulated RANK Osteoclastogenesis alteration [51]
miR-133a Upregulated RUNX2 Osteoclast differentiation and loss of bone density [52]
miR-363-3p Upregulated PTEN Osteoclastogenesis promotion and inhibition of osteogenic differentiation [41]
miR-29a Downregulated RANKL Osteoclastogenic differentiation [55]
miR-152 Upregulated RICTOR Inhibition of osteoblast differentiation [35]
miR-579-3p Upregulated SIRT1 Inhibition of osteogenic differentiation [57]
miR-200a-3p Upregulated GLS Inhibition of osteogenic differentiation [58]
miR-140-5p Downregulated BMP2 Enhancement of osteogenic differentiation [59]
miR-339 Downregulated DLX5 Enhancement of osteogenic differentiation [60]
miR-140-3p Upregulated MCF2L Inhibition of preosteoblast viability and induction of preosteoblast apoptosis [61]
miR-194-5p Upregulated WNT5A Inhibition of bone formation and osteoblast/osteogenic differentiation [62]
miR-1286 Upregulated FZD4 Inhibition of osteogenic differentiation [63]
miR-483-5p Upregulated IGF2 Promotion of osteoclast differentiation [34]
miR-203a Upregulated DLX5 Osteogenic differentiation delay and bone loss [40]
miR-10a-3p Downregulated (by a kaempferol treatment) CXCL12 Promotion of osteogenic differentiation [64]
miR-300 Downregulated CUL4B Degradation of PTEN (tumor suppressor) [71]
miR-93 Upregulated P21 Proliferation of osteosarcoma cells [72]
miR-411 Upregulated MTSS1 Osteosarcoma cell migration and proliferation [73]
miR-1284 Downregulated HMGB1 Osteosarcoma cell migration and proliferation [76]
let-7a Downregulated E2F2 Osteosarcoma development [77]
miR-1301 Downregulated BCL9 Cell proliferation, invasion, and migration [81]
miR-487a Upregulated - - [82]
miR-493-5p Upregulated - -
miR-501-3p Upregulated - -
miR-502-5p Upregulated - -
hsa-miR-19-3p Upregulated Several transcription factors Cell proliferation and carcinogenesis [83]
hsa-miR-106b-3p Upregulated
hsa-miR-543 Downregulated ZNRD1 Osteosarcoma chemoresistance [84]
Osteonecrosis hsa-miR-195-5p Downregulated 157 different genes Osteoblast dissemination disruption, accelerated cell apoptosis, and collapse of the femoral head [94]
hsa-miR-601 Upregulated 238 different genes Adipogenic and osteogenic differentiation [87]
hsa-miR-452-3p Upregulated Adipogenic and osteogenic differentiation
hsa-miR-647 Upregulated Adipogenic and osteogenic differentiation
hsa-miR-516b-5p Upregulated Adipogenic and osteogenic differentiation
hsa-miR-127-5p Upregulated Adipogenic and osteogenic differentiation
hsa-miR-122-3p Downregulated Adipogenic and osteogenic differentiation
miR-181d Upregulated SMAD3 Inhibition of osteogenic differentiation [88]
miR-217 Downregulated DKK1 Inhibition of cell proliferation and osteogenic differentiation [96]
miR-214 Upregulated ATF4 and PTEN Inhibition of osteoblast differentiation and promotion of osteoclast function [97]
miR-186-5p Upregulated CXCL13 Alteration of cell viability and osteoblastic differentiation [89]
miR-410 Downregulated Wnt-11 High levels of osteoclasts and low levels of osteoblasts. Low bone mineral density [98]
miR-93-5p Upregulated - - [86]
miR-320a Upregulated - -
hsa-miR-378-c Upregulated WNT3A, DACT1 and CSF1 Bone remodeling and angiogenesis during ONFH [99]
hsa-let-7a-5p Upregulated RCAN2 and IL9R Progression of ONFH
hsa-miR-3200-5p Upregulated RELN Progression of ONFH
hsa-miR-28-5p Upregulated RELA Cartilage degeneration
hsa-miR-532-5p Upregulated CLDN18 and CLDN10 Bone loss
Bone Metastasis miR-466 Downregulated RUNX2 Inhibition of apoptosis and cell cycle arrest. Cell migration, proliferation, and invasion [109]
miR-19a-3p Downregulated SMAD2 and SMAD4 Cell migration, invasion, and bone metastasis [110]
miR-582-3p Downregulated SMAD2, SMAD4, and TGFBR1 Cell migration, invasion, and metastasis [111]
miR-582-5p Downregulated SMAD2, TGFBR1 and TGFBR2
miR-96 Upregulated E-Cadherin and EpCAM Cancer cell metastasis within bone microenvironment and tumor development [113]
miR-214-3p Upregulated TRAF3 Osteolytic bone metastasis and elevated bone resorption [116]
miR-124 Downregulated IL-11 Bone metastasis of breast cancer cells [117]
miR-139-5p Downregulated NOTCH1 Osteogenic differentiation and lytic bone disease in lung cancer [118]
miR-34a Downregulated C-IAP2 and Bcl-2 Tumor invasion and metastasis [120]
hsa-miR-940 Upregulated ARHGAP1 and FAM134A Osteogenic differentiation and induction of osteoblastic lesions in tumors [121]
Atrophic non-union miR-31a-3p Upregulated FGF3 Osteogenesis, chondrogenesis, and impairment of fracture healing [131]
miR-31a-5p Upregulated SATB2, Osterix, RUNX2, BMPR2, and NIK Osteogenic differentiation
miR-146a-5p Upregulated TRAF6, IRAK1, CXCR4, and SDF-1 Development of non-union
miR-146b-5p Upregulated TRAF6 and IRAK1 Development of non-union
miR-223-3p Upregulated STAT3 and IGF1R Development of non-union
miR-628-3p Upregulated RUNX2 Inhibition of osteoblast differentiation [129]
miR-381 Upregulated WNT5A and FZD3 Inhibition of osteogenic differentiation [132]
miR-1323 Upregulated BMP4 and SMAD4 Inhibition of osteogenic differentiation and development of atrophic non-union [133]
hsa-miR-149* Upregulated ALPL Development of atrophic non-union [134]
hsa-miR-221 Upregulated PDGFA Development of atrophic non-union
hsa-miR-654-5p Upregulated BMP2 Development of atrophic non-union
Osteogenesis imperfecta miR-29b Downregulated - Altered regulation of collagen protein accumulation [135]
miR-145 Upregulated (by an ossotide treatment) RUNX2 and OSX Enhancement of osteoblast cell differentiation and proliferation [137]
Osteomyelitis miR-24 Downregulated CHI3L1 Inhibition of cell proliferation, blockage of both bone formation and mineralization, and osteoblast apoptosis [143]
miR-129-5p Upregulated eNOS Occurrence of mineralization defect and progression of osteomyelitis [146]
Multiple myeloma miR-29b Downregulated Mcl-1 Survival ofmyeloma cells [150]
miR-143 Downregulated Versican Myeloma-associated parameters [152]
miR-144 Downregulated
miR-199 Downregulated
miR-203 Downregulated
Thalassemia miR-30a Upregulated BCL11A Increased expression levels of HbF and a decreased expression levels of ferritin [156]
miR-15a Upregulated MAF proteins and MYB HbF induction [154]
miR-486-3p Upregulated MAFK, BCL11A, MTA1, and NR2F2