Table 3.
Mean sum FIC50 values for artemether and lumefantrine combinations with S. longipedunculata extracts against D6 strain of P. falciparum.
| Fixed Ratios Drug:Extract |
ART-Roots | ART-Stems | ART-Leaves | LU-Roots | LU-Stems | LU-Leaves |
|---|---|---|---|---|---|---|
| 4:1 | 0.425 ± 0.347 | 0.9 ± 0.255 | 0.65 ± 0.383 | 0.677 ± 0.251 | 1.435 ± 0.892 | 0.292 ± 0.133 |
| 3:1 | 0.468 ± 0.278 | 0.892 ± 0.446 | 0.664 ± 0.28 | 0.916 ± 0.427 | 0.956 ± 0.335 | 0.856 ± 0.307 |
| 1:1 | 0.43 ± 0.536 | 0.787 ± 0.434 | 0.763 ± 0.443 | 0.684 ± 0.173 | 2.27 ± 1.762 | 0.554 ± 0.161 |
| 1:2 | 0.342 ± 0.333 | 0.763 ± 0.238 | 1.147 ± 0.688 | 0.631 ± 0.213 | 0.613 ± 0.549 | 0.936 ± 0.523 |
| 1:3 | 0.471 ± 0.377 | 0.534 ± 0.251 | 0.959 ± 0.577 | 0.735 ± 0.306 | 1.924 ± 1.497 | 1.379 ± 0.641 |
| 1:4 | 0.284 ± 0.159 | 0.678 ± 0.145 | 1.132 ± 0.595 | 0.785 ± 0.427 | 1.351 ± 1.03 | 1.993 ± 1.094 |
Number of replicates: 4; ART: artemether; LU: lumefantrine; D6: mefloquine-resistant, chloroquine-sensitive strain of P. falciparum; FIC50: synergism < 1, additivity 1, antagonism > 1; values are 50% inhibition concentration means ± standard deviation.