Table 5.
Mean of mean sum FIC50s values across all fixed ratios for artemether and lumefantrine combined with S. longipedunculata extracts against strains of P. falciparum.
| ART-Roots | ART-Stems | ART-Leaves | LU-Roots | LU-Stems | LU-Leaves | |
|---|---|---|---|---|---|---|
| D6 | 0.403 ± 0.068 a | 0.756 ± 0.126 b | 0.886 ± 0.206 | 0.738 ± 0.093 c | 1.425 ± 0.555 a,b,c | 1.001 ± 0.556 |
| W2 | 0.856 ± 0.448 a | NT | 2.065 ± 0.944 a,b,c | 0.75 ± 0.207 b | NT | 0.456 ± 0.165 c |
| DD2 | 0.896 ± 0.148 a,b | 0.485 ± 0.176 a | NT | 0.629 ± 0.18 | 0.376 ± 0.096 b | NT |
| Field isolates * | 0.805 ± 0.229 | 0.656 ± 0.067 | 0.705 ± 0.398 | 1.064 ± 0.996 | 0.807 ± 0.218 | 0.825 ± 0.252 |
NT: not tested; ART: artemether; LU: lumefantrine; D6: mefloquine-resistant, chloroquine-sensitive; W2: chloroquine-resistant, mefloquine sensitive; DD2: chloroquine-resistant, mefloquine-resistant strains of P. falciparum; FIC50: synergism < 1, additivity 1, antagonism > 1; * p value is not statistically significant; values are 50% inhibition concentration means ± standard deviation; a,b,c: Combinations with same superscript letters are significantly similar.