Table 2.
Results of Pulmonary Function Testing of Patients with Sarcoidosis and Healthy Controls
| Tests | Patients (n = 57) | Controls (n = 50) | p-value |
|---|---|---|---|
| Spirometry | |||
| FVC (L) | 3.57 (3.10–4.19) | 4.03 (3.57–4.62) | 0.002 |
| FVC (%) | 84.00 (78.00–90.00) | 92.50 (89.00 −103.00) | <0.001 |
| FEV1 (L) | 2.85 (2.21–3.26) | 3.21 (2.99–3.69) | <0.001 |
| FEV1 (%) | 80.00 (69.00–86.00) | 94.00 (85.00–100.00) | <0.001 |
| FEV1/FVC (L) | 78.00 (74.00–82.00) | 80.00 (77.00–87.00) | 0.044 |
| Lung volumes | |||
| TCL (L) | 83.00 (71.00–91.00) | 89.00 (85.00–97.00) | 0.001 |
| RV (L) | 83.00 (74.00–92.00) | 90.50 (83.00–97.00) | 0.001 |
| Maximal respiratory pressures | |||
| MIP (cmH2O) | 87.51 (78.57–100.52) | 90.99 (78.14–111.96) | 0.002 |
| MIP (%) | 84.00 (79.00–91.00) | 90.00 (83.00–97.00) | 0.001 |
| MEP (cmH2O) | 95.46 (76.10–109.73) | 92.12 (78.85–114.10) | 0.009 |
| MEP (%) | 85.00 (79.00–89.00) | 89.00 (85.00–92.00) | < 0.001 |
| Diffusing capacity | |||
| DLCO (%) | 20.43 (18.45–24.82) | 26.13 (21.31–36.24) | <0.001 |
| DLCOcorr (%) | 84.00 (70.00–91.00) | 92.50 (89.00–94.00) | <0.001 |
| Physical activity | |||
| 6MWD (m) | 496.00 (437.00–550.00) | 561.00 (531.00–586.00) | <0.001 |
| 6MWDpred (%) | 93.00 (86.00–96.00) | 97.50 (93.00–100.00) | <0.001 |
Notes: Data are presented as median (inter-quartile range).
Abbreviations: FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; MIP, maximal inspiratory pressure; MEP, maximal expiratory pressure; DLCO, diffusing capacity of lung for carbon monoxide; 6MWD, six-minute walking distance.