Table 2.
Effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) or paroxetine or donepezil on the activity of monoamine oxidase (MAO)-A and B isoforms in the prefrontal cortex and hippocampus of mice subjected to acute restraint stress (ARS)
| Prefrontal cortex | Hippocampus | |||
|---|---|---|---|---|
| Experimental groups | MAO A | MAO B | MAO A | MAO B |
| Non-stressed – control | 0.54 ± 0.09 | 0.65 ± 0.06 | 0.99 ± 0.09 | 1.05 ± 0.09 |
| Non-stressed – 4-PSQ | 0.82 ± 0.05 | 0.55 ± 0.11 | 1.65 ± 0.30 | 1.60 ± 0.06 |
| ARS—stressed | 1.73 ± 0.12**** | 1.22 ± 0.09** | 2.26 ± 0.14** | 1.71 ± 0.11** |
| ARS – 4-PSQ | 0.42 ± 0.04#### | 0.68 ± 0.08# | 1.05 ± 0.12## | 1.11 ± 0.16# |
| ARS—Paroxetine | 1.46 ± 0.15 ****& | 0.93 ± 0.14 | 1.28 ± 0.20# | 1.28 ± 0.12 |
| ARS—Donepezil | 1.45 ± 0.15****& | 1.16 ± 0.15* | 2.70 ± 0.30****& | 1.58 ± 0.17 |
Values are expressed as mean ± standard error of the mean (S.E.M.) (n = 7). (**) denotes p < 0.01 and (****) denotes p < 0.0001 when compared to the non-stressed control group. (#) denotes p < 0.05, (##) denotes p < 0.01, and (####) denotes p < 0.0001 when compared to the ARS-induced group. (&) denotes p < 0.05 when compared to the ARS + 4-PSQ group (one-way ANOVA followed by Tukey’s test)