Table 3.

The top 20 signaling pathways with related genes.

Term	Pathway	Genes	P value
hsa05200	Pathways in cancer	JUN, NOS2, MMP2, PTGER3, PTGS2, MMP9, EGFR, PGF, IGF1R, VEGFA, AR, PIK3CA, MDM2, AGTR1, AKT1, RARB, PPARG, BCL2L1, MAPK3	4.30E − 11
hsa05205	Proteoglycans in cancer	SRC, MMP2, ESR1, TNF, MMP9, EGFR, IGF1R, VEGFA, PIK3CA, MDM2, KDR, AKT1, MAPK3	7.30E − 09
hsa04014	Ras signaling pathway	PIK3CA, PLA2G1B, KDR, PLA2G4A, AKT1, EGFR, PGF, BCL2L1, IGF1R, MAPK3, VEGFA	2.62E − 06
hsa04151	PI3K-Akt signaling pathway	PIK3CA, MDM2, KDR, AKT1, EGFR, PGF, BCL2L1, IGF1R, MCL1, MAPK3, VEGFA	1.05E − 04
hsa04510	Focal adhesion	JUN, PIK3CA, SRC, KDR, AKT1, EGFR, PGF, IGF1R, MAPK3, VEGFA	9.89E − 06
hsa04015	Rap1 signaling pathway	PIK3CA, CNR1, SRC, KDR, AKT1, EGFR, PGF, IGF1R, MAPK3, VEGFA	1.16E − 05
hsa04915	Estrogen signaling pathway	JUN, PIK3CA, SRC, MMP2, AKT1, ESR1, MMP9, EGFR, MAPK3	3.25E − 07
hsa04370	VEGF signaling pathway	PIK3CA, SRC, KDR, PLA2G4A, AKT1, PTGS2, MAPK3, VEGFA	1.68E − 07
hsa04066	HIF-1 signaling pathway	PIK3CA, NOS2, SERPINE1, AKT1, EGFR, IGF1R, MAPK3, VEGFA	3.82E − 06
hsa05142	Chagas disease (American trypanosomiasis)	JUN, ACE, PIK3CA, NOS2, SERPINE1, AKT1, TNF, MAPK3	6.52E − 06
hsa04668	TNF signaling pathway	JUN, PIK3CA, MMP3, AKT1, PTGS2, TNF, MMP9, MAPK3	7.88E − 06
hsa05202	Transcriptional misregulation in cancer	IGFBP3, MMP3, MDM2, PPARG, MPO, MMP9, BCL2L1, IGF1R	1.39E − 04
hsa05219	Bladder cancer	SRC, MMP2, MDM2, MMP9, EGFR, MAPK3, VEGFA	3.13E − 07
hsa05215	Prostate cancer	AR, PIK3CA, MDM2, AKT1, EGFR, IGF1R, MAPK3	2.94E − 05
hsa05161	Hepatitis B	JUN, PIK3CA, SRC, AKT1, TNF, MMP9, MAPK3	4.68E − 04
hsa05164	Influenza A	JUN, PIK3CA, NLRP3, AKT1, PLG, TNF, MAPK3	0.001220965
hsa04024	cAMP signaling pathway	JUN, PIK3CA, PTGER3, PDE4A, AKT1, PPARA, MAPK3	0.002361912
hsa05206	MicroRNAs in cancer	ABCB1, MDM2, PTGS2, MMP9, EGFR, MCL1, VEGFA	0.013841455
hsa05212	Pancreatic cancer	PIK3CA, AKT1, EGFR, BCL2L1, MAPK3, VEGFA	8.07E − 05
hsa05214	Glioma	PIK3CA, MDM2, AKT1, EGFR, IGF1R, MAPK3	8.07E − 05