Table 5.
The diagnostic efficiency of anti-PLA2R detected by the ELISA kit (EUROIMMUN, Germany)
| Country | Time range | Cutoff, RU/mL | Sensitivity, % | Specificity, % | PPV, % | NPV, % | Youden index | AUC | References |
|---|---|---|---|---|---|---|---|---|---|
| Netherlands | 11/1979–03/2011 | 2 | 71.56 (78/109) | 96.97 (32/33) | 98.73 (78/79) | 50.79 (32/63) | 0.69 | - | Timmermans et al. [15] |
| 20 | 63.30 (69/109) | 96.97 (32/33) | 98.57 (69/70) | 44.44 (32/72) | 0.60 | ||||
| Greece | - | 2 | 57.58 (19/33) | - | - | - | - | - | Provatopoulou et al. [16] |
| - | 14 | 48.48 (16/33) | - | - | - | - | - | ||
| - | 20 | 48.48 (16/33) | - | - | - | - | - | ||
| India | 07/2010–02/2015 | 20 | 66.67 (76/114) | - | - | - | - | - | Ramachandran et al. [26] |
| Korea | 01/2007–04/2014 | 14 | 44.09 (41/93) | 100.00 (67/67) | 100.00 (41/41) | 56.30 (67/119) | 0.44 | - | Kim et al. [20] |
| Japan | 06/1993–12/2014 | 20 | 50.00 (19/38) | 100.00 (21/21) | 100.00 (19/19) | 52.50 (21/40) | 0.50 | - | Hihara et al. [22] |
| Japan | 2001–2014 | 20 | 52.17 (12/23) | 100.00 (32/32) | 100.00 (12/12) | 74.42 (32/43) | 0.52 | - | Katsumata et al. [21] |
| China | - | 15 | 71.67 (86/120) | - | - | - | - | - | Xun et al. [18] |
| China | 01/2011–12/2013 | 20 | 62.20 (51/82) | 91.46 (75/82) | 87.93 (51/58) | 70.75 (75/106) | 0.54 | - | Li et al. [19] |
| China | 08/2014–12/2014 | 14 | 65.25 (77/118) | 97.30 (108/111) | 96.25 (77/80) | 72.48 (108/149) | 0.63 | 0.870a | Dou et al. [23] |
| 20 | 60.17 (71/118) | 97.30 (108/111) | 95.95 (71/74) | 69.68 (108/155) | 0.58 | ||||
| 40 | 45.76 (54/118) | 97.30 (108/111) | 94.77 (54/57) | 62.79 (108/172) | 0.43 | ||||
| China | 09/2011–03/2016 | 2 | 82.46 (47/57) | 75.00 (63/84) | 69.12 (47/68) | 86.30 (63/73) | 0.59 | 0.879a | Liu et al. [24] |
| 2.6 | 78.95 (45/57) | 91.67 (77/84) | 86.54 (45/52) | 86.52 (77/89) | 0.71 | ||||
| 14 | 59.65 (34/57) | 95.24 (80/84) | 89.47 (34/38) | 77.67 (80/103) | 0.55 | ||||
| 20 | 50.88 (29/57) | 96.43 (81/84) | 90.63 (29/32) | 74.31 (81/109) | 0.46 | ||||
| 40 | 47.37 (27/57) | 97.62 (82/84) | 93.10 (27/29) | 73.21 (82/112) | 0.43 | ||||
| China | 04/2016–06/2017 | 20 | 67.26 (76/113) | 98.85 (86/87) | 98.70 (76/77) | 69.92 (86/123) | 0.66 | 0.90b | Li et al. [25] |
PLA2R, phospholipase A2 receptor; ELISA, enzyme-linked immunosorbent assay; PPV, positive predictive value; NPV, negative predictive value; AUC, area under receiver operating characteristic curve.
a
Differential diagnosis between idiopathic membranous nephropathy (IMN) and non-IMN.
b
Differential diagnosis between IMN and secondary membranous nephropathy.