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. 2021 Dec;12(6):3155–3162. doi: 10.21037/jgo-21-300

Table 1. Timelines of significant events in Case #1 and #2.

Case Time Event
#1 >6 years before presentation HIV/AIDS and other co-morbidities
6 years before presentation HGSIL grade 1/2 of the cervix not treated
1 year before presentation HGSIL grade 3, cervical conization
Initial presentation Presents with anal margin mass, growing over 8 months
3 weeks Examination, biopsy, imaging, pathologic diagnosis of anal squamous cell carcinoma (SCC); no evidence of metastasis
5 weeks Start of CRT; P1 TTMV measurement
9 weeks T1 TTMV measurement
4 months End of (incomplete) chemoRT
6 months Post-treatment follow up, suspected recurrence; S1 TTMV measurement
8 months Presents with anal pain, PET/CT1 suggestive of recurrence; pathologic diagnosis of locally recurrent anal SCC
9 months S2 TTMV measurement
11 months Progressive local disease; diverting colostomy; S3 TTMV measurement; initiation of salvage chemotherapy
12 months PET/CT2 and cycle 2 salvage chemotherapy
14 months S4 TTMV measurement; initiation of salvage chemoRT
16 months Interval response of disease on clinical exam during chemoRT; T2 TTMV measurement
#2 2 years before presentation Prostate cancer diagnosis; active surveillance pursued
Initial presentation Presents with rising PSA with planned surveillance prostate biopsy
Examination, PET/CT, and anorectal biopsy; pathologic diagnosis of anal SCC; no evidence of metastasis
4 weeks P1 TTMV measurement; start of chemoRT
8 weeks T1 TTMV measurement
10 weeks End of chemoRT
3 months S1 TTMV measurement
5 months Anoscopy with firmness and ulceration suspicious for residual cancer; PET/CT with complete response; PSA 0.81; S2 TTMV measurement
8 months Exam under anesthesia #1 with biopsy negative; S3 TTMV measurement
12 months Exam under anesthesia #2 with biopsy negative; PET/CT with suspicious uptake in low rectum; PSA 0.37; S4 TTMV measurement
15 months Exam under anesthesia #3 with biopsy negative; PET/CT negative; PSA 0.38; S5 TTMV measurement