#1 |
>6 years before presentation |
HIV/AIDS and other co-morbidities |
|
6 years before presentation |
HGSIL grade 1/2 of the cervix not treated |
|
1 year before presentation |
HGSIL grade 3, cervical conization |
|
Initial presentation |
Presents with anal margin mass, growing over 8 months |
|
3 weeks |
Examination, biopsy, imaging, pathologic diagnosis of anal squamous cell carcinoma (SCC); no evidence of metastasis |
|
5 weeks |
Start of CRT; P1 TTMV measurement |
|
9 weeks |
T1 TTMV measurement |
|
4 months |
End of (incomplete) chemoRT |
|
6 months |
Post-treatment follow up, suspected recurrence; S1 TTMV measurement |
|
8 months |
Presents with anal pain, PET/CT1 suggestive of recurrence; pathologic diagnosis of locally recurrent anal SCC |
|
9 months |
S2 TTMV measurement |
|
11 months |
Progressive local disease; diverting colostomy; S3 TTMV measurement; initiation of salvage chemotherapy |
|
12 months |
PET/CT2 and cycle 2 salvage chemotherapy |
|
14 months |
S4 TTMV measurement; initiation of salvage chemoRT |
|
16 months |
Interval response of disease on clinical exam during chemoRT; T2 TTMV measurement |
#2 |
2 years before presentation |
Prostate cancer diagnosis; active surveillance pursued |
|
Initial presentation |
Presents with rising PSA with planned surveillance prostate biopsy |
|
|
Examination, PET/CT, and anorectal biopsy; pathologic diagnosis of anal SCC; no evidence of metastasis |
|
4 weeks |
P1 TTMV measurement; start of chemoRT |
|
8 weeks |
T1 TTMV measurement |
|
10 weeks |
End of chemoRT |
|
3 months |
S1 TTMV measurement |
|
5 months |
Anoscopy with firmness and ulceration suspicious for residual cancer; PET/CT with complete response; PSA 0.81; S2 TTMV measurement |
|
8 months |
Exam under anesthesia #1 with biopsy negative; S3 TTMV measurement |
|
12 months |
Exam under anesthesia #2 with biopsy negative; PET/CT with suspicious uptake in low rectum; PSA 0.37; S4 TTMV measurement |
|
15 months |
Exam under anesthesia #3 with biopsy negative; PET/CT negative; PSA 0.38; S5 TTMV measurement |