Table 1.
Comparison of demographics, blood analysis, CT, and FibroScan data prior to treatment
| Variables | Group 1 | Group 2 | Group 3 | Group 4 | F/χ2 value | P value |
|---|---|---|---|---|---|---|
| Cases | 40 | 50 | 44 | 30 | ||
| Age (yr) | 43.23±10.32 | 45.78±9.79 | 44.64±10.13 | 44.97±10.03 | 0.487 | 0.692 |
| Gender (M/F) | 24/16 | 31/19 | 26/18 | 18/12 | 0.090 | 0.993 |
| Weight (kg) | 61.21±7.87 | 66.89±7.37 | 77.67±9.00 | 86.65±9.32 | 66.512 | <0.001 |
| Height (m) | 1.71±0.08 | 1.70±0.07 | 1.70±0.07 | 1.69±0.07 | 0.309 | 0.819 |
| BMI (kg/m2) | 20.90±1.43 | 22.99±1.60 | 26.98±2.05 | 30.09±1.70 | 206.955 | <0.001 |
| Cr (µmmol/L) | 62.29±10.15 | 65.24±10.65 | 65.32±9.48 | 64.71±10.02 | 0.822 | 0.483 |
| ALT (U/L) | 23.29±8.90 | 51.95±12.56 | 80.78±13.48 | 107.05±13.57 | 314.269 | <0.001 |
| AST (U/L) | 19.19±8.62 | 37.61±10.17 | 64.95±11.03 | 83.45±11.89 | 273.965 | <0.001 |
| GGT (U/L) | 23.19±9.96 | 44.38±11.39 | 82.26±13.70 | 100.74±14.47 | 300.529 | <0.001 |
| TB (µmol/L) | 10.84±3.77 | 11.69±3.72 | 12.43±3.99 | 15.55±4.53 | 8.936 | <0.001 |
| ALB (g/L) | 47.77±4.00 | 48.08±4.03 | 46.87±3.26 | 47.40±3.42 | 0.894 | 0.445 |
| TG (mmol/L) | 1.03±0.35 | 1.90±0.40 | 2.61±0.50 | 3.48±0.53 | 195.923 | <0.001 |
| TC (mmol/L) | 4.11±0.81 | 5.17±1.06 | 6.29±0.94 | 7.23±1.15 | 67.504 | <0.001 |
| HDL (mmol/L) | 1.35±0.35 | 1.21±0.24 | 1.08±0.25 | 0.92±0.27 | 15.908 | <0.001 |
| LDL (mmol/L) | 1.77±0.59 | 2.56±0.80 | 3.51±0.95 | 4.40±0.90 | 69.123 | <0.001 |
| FBG (mmol/L) | 5.06±0.66 | 5.38±0.78 | 5.71±0.84 | 6.18±0.76 | 13.799 | <0.001 |
| FINS (mU/L) | 7.30±1.81 | 11.45±2.50 | 18.31±2.23 | 22.87±2.44 | 343.172 | <0.001 |
| HOMA-IR | 1.63±0.43 | 2.74±0.71 | 4.62±0.72 | 6.25±0.74 | 342.558 | <0.001 |
| liver/spleen CT ratio | 1.12±0.06 | 0.84±0.08 | 0.60±0.05 | 0.30±0.08 | 932.026 | <0.001 |
| LSM (Kpa) | 5.88±0.79 | 7.13±0.87 | 9.06±1.26 | 13.61±1.49 | 320.957 | <0.001 |
Notes: Group 1 is healthy controls, Group 2 is mild fatty liver, Group 3 is moderate fatty liver, and Group 4 is severe fatty liver. Abbreviations: BMI: body mass index; Cr: creatinine; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: glutamyl transpeptidase; TB: total bilirubin; ALB: albumin; TG: triglyceride; TC: total cholesterol; HDL: high density lipoprotein cholesterol; LDL: low density lipoprotein cholesterol; FBG: fasting plasma glucose; FINS: fasting serum insulin; HOMA-IR: homeostasis model assessment of insulin resistance; LSM: liver stiffness measurement.