Figure 7.

Therapeutic effects of different doses of CUR in AD mouse models. We evaluated the cognitive and motor functions of mice in APP/PS-1 group (n=10), low dose group (n=10), middle dose group (n=10) and high dose group (n=10), escape latency (A), platform crossing times (B), target quadrant stay time (C), and swimming speed (D) by MWM test. The effects of different doses of CUR on the pathological characteristics of cortex and hippocampus of mice (scale bar =30 µm) (E, F) were analyzed qualitatively and quantitatively by HE staining (×200), and the effects of different doses of CUR on the accumulation of Aβ in brain tissue of mice were detected by immunohistochemistry (×200) (scale bar =30 µm) (G). Note: *P<0.05, **P<0.01 vs. AD group, ^a P<0.05 vs. low-dose group, ^b P<0.05 vs. moderate-dose group.