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IC50 values for the four KIT-inhibiting TKIs in GIST cell groups
| IC50 (nM) | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| GIST-T1-vector | GIST-T1-V654A | GIST-T1-N822K | GIST-882-vector | GIST-882-V654A | GIST-882-N822K | |
| Sunitinib | 15.91 | 13.02 | 61.05 | 4.17 | 29.34 | >1000 |
| Regorafenib | 88.97 | 134.50 | 13.29 | 116.20 | 80.27 | 18.07 |
| Avapritinib | 139.70 | 213.10 | 30.50 | 161.70 | 221.40 | 119.50 |
| Ripretinib | 53.21 | >1000 | 19.53 | 470.20 | 1972 | 345.30 |
