Table 4.
MOAA/S and BIS values assessment
| 0.4 mg/kg (N = 6) | 0.6 mg/kg (N = 6) | 0.9 mg/kg (N = 6) | |
|---|---|---|---|
| LORverbal, n (%) | 5 (83.3) | 6 (100) | 6 (100) |
| RORverbal, n (%) | 5 (100) | 6 (100) | 6 (100) |
| TLORverbal (min) | 2.0 (2.0, 2.0) | 2.0 (2.0, 2.0) | 1.0 (1.0, 1.0) |
| TRORverbal (min) | 8.0 (7.0, 8.0) | 10.0 (7.0, 10.0) | 15.0 (14.0, 17.0) |
| LORverbal duration (min) | 6.0 (5.0, 6.0) | 8.0 (5.0, 8.0) | 14.0 (13.0, 16.0) |
| Talert (min) | 7.0 (6.0, 8.0) | 9.5 (9.0, 11.0) | 19.0 (16.0, 21.0) |
| MOAA/S ≤1, n (%) | 5 (83.3) | 6 (100) | 6 (100) |
| MOAA/S ≤1, duration (min) | 5.0 (4.0, 5.0) | 5.5 (3.0, 7.0) | 13.5 (12.0, 15.0) |
| MOAA/S = 0, n (%) | 5 (83.3) | 2 (33.3) | 4 (66.7) |
| MOAA/S = 0, duration (min) | 2.0 (1.0, 4.0) | 2.0 (1.0, 3.0) | 6.0 (3.5, 11.5) |
| BISpeak | 41.0 (38.0, 48.0) | 34.5 (28.0, 37.0) | 29.0 (26.0, 33.0) |
| TBISpeak (min) | 3.0 (3.0, 4.0) | 2.5 (2.0, 3.0) | 2.5 (2.0, 4.0) |
| BIS at LORverbal | 56.0 (44.0, 57.0) | 38.0 (32.0, 44.0) | 89.0 (85.0, 96.0) |
| BIS at RORverbal | 60.0 (60.0, 63.0) | 52.5 (47.0, 57.0) | 61.0 (60.0, 64.0) |
Note: Data are presented as medians (1st to 3rd quartile) and numbers with percentages. LORverbal: loss of the verbal response when MOAA/S <3; RORverbal: recovery of the verbal response when MOAA/S ≥3; TLORverbal (min): duration of loss of the verbal response; TRORverbal (min): duration of recovery of the verbal response; LORverbal duration (min): duration of LORverbal and RORverbal; Talert (min): duration of return of responsiveness (duration of first record of MOAA/S <5 after drug administration to the first record of 3 consecutive MOAA/S = 5); BISpeak: peak BIS value; TBISpeak: the duration when the peak BIS value was reached; BIS at LORverbal: BIS value at loss of the verbal response; BIS at RORverbal: BIS value when recovery of the verbal response.