Table 5.
Population PK/PD parameters after ciprofol injection
| Parameters | Estimated value | 1,000 Bootstrapped | |
|---|---|---|---|
|
| |||
| Median | 95% CI | ||
| Final PK model | |||
| V1 (L) | 20.5 | 20.6 | 13.1-26.4 |
| V2 (L) | 176 | 182.7 | 116.4-290.2 |
| V3 (L) | 61.7 | 60.9 | 16.4-90.4 |
| CL1 (L/min) | 1.1 | 1.1 | 0.7-1.3 |
| CL2 (L/min) | 1.3 | 1.3 | 0.7-2.9 |
| CL3 (L/min) | 3.3 | 3.3 | 1.9-4.4 |
| Tlag (min) | 0.4 | 0.4 | 0.2-0.5 |
| Final BIS PD model (sigmoid Emax model) | |||
| E0, BIS | 94.5 | 94.6 | 93.5-95.8 |
| Emax, BIS | 37.1 | 36.4 | 31.7-40.9 |
| Ce50 (ng/mL) | 284.0 | 285.6 | 253.2-332.8 |
| Keo (min-1) | 2.2 | 2.3 | 1.1-5.5 |
| Telag (min) | 0.5 | 0.5 | 0.4-0.6 |
| Final MOAA/S PD model (sigmoid Emax model) | |||
| E0, MOAA/S | 4.7 | 4.7 | 4.4-5.0 |
| Emax, MOAA/S | 0.8 | 1.0 | 0.5-1.1 |
| Ce50 (ng/mL) | 326.0 | 325.0 | 272.0-365.0 |
| Keo (min-1) | 0.6 | 0.7 | 0.5-1.2 |