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. 2021 Sep 2;46(1):39–49. doi: 10.1038/s41366-021-00957-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Mean plasma insulin (n = 15–20 mice per group) (A) and venous plasma glucose (n = 9–11 mice per group) (B) in pups raised in small (orange), normal (gray), or large (blue) litters measured on postnatal day 10 during the peak of plasma leptin surge. Regression of plasma leptin concentrations (C) or fat mass (D) vs. insulin for each of the litter size group. Difference in plasma insulin and glucose concentrations among the groups were tested with one-way ANOVA with Tukey post hoc at the 5% level of significance; ***p < 0.001; ns denotes nonsignificant difference.