FIGURE 3.

MLST8 is upregulated in ccRCC specimens and predicts poor clinical outcomes in ccRCC patients. A, Expression of MLST8 increased as ccRCC progressed to more advanced stages. MLST8 protein expression was accessed by IHC analysis in 79 paired ccRCC specimens. B, Box plots of MLST8 protein expression based on their staining index in normal renal normal tissues and ccRCC specimens. C, Box plots of MLST8 protein expression based on different clinical stages. D, Box plots of MLST8 protein expression based on IS at different clinical stages. G1, G2, G3, and G4 represent well‐differentiated, moderately differentiated, and poorly differentiated tumors, respectively. E, OS curve of ccRCC patients based on MLST8 expression according to Kaplan‐Meier analysis. Patients with high levels of MLST8 were associated with poor survival (P = .0183)