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. 2021 Nov 16;113(1):91–108. doi: 10.1111/cas.15188

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© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Downexpression of MLST8 inhibits ccRCC metastasis. A, Xenograft tumor formation assays show that downexpression of MLST8 inhibits subcutaneous tumor formation capacity. B, Immunohistochemical analysis of MLST8 and Ki67 expression in subcutaneous tumors. C and D, Tumor weight and tumor growth of xenografts of MLST8‐knocking out 786‐O stable cells in nude mice, respectively. E and F, Images showing intrahepatic metastasis and morphological characters by HE staining, respectively. **P < .01. All assays were conducted in triplicate