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Ligand‐independent activation of the RET fusion protein. RET fusions maintain the tyrosine kinase domain of the 3′ RET gene. A variety of fusion partners contribute different domains, such as coiled‑coil, to RET fusion proteins. These motifs mediate ligand‑independent dimerization of the RET fusion protein. Identification and annotation of genetically mobile domains and analysis of domain architectures (http://smart.embl‐heidelberg.de/)
