TABLE 3.
Relationship between T‐cell enrichment scores and clinical parameters in 520 patients with HNSCC
| Variables | CD4+ T cells | Th1 cells | Th2 cells | Tregs | CD8+ T cells | CD8+ TN | CD8+ TCM | CD8+ TEM |
|---|---|---|---|---|---|---|---|---|
| Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | Mean (SE) ×10−3 | |
| HPV status | ||||||||
| Negative | 1.32 (0.199) | 69.7 (3.53) | 114 (3.64) | 7.98 (0.731) | 23.5 (1.53) | 9.55 (0.443) | 18.3 (1.43) | 8.06 (0.797) |
| Positive | 4.82 (1.22) | 91.9 (7.76) | 131 (6.35) | 8.33 (1.55) | 36.6 (4.95) | 11.3 (1.25) | 45.2 (5.66) | 14.15 (2.96) |
| P‐value | <.0001 | .007 | .04 | .84 | .001 | .11 | <.0001 | .006 |
| Primary lesion | ||||||||
| Hypopharynx | 1.15 (0.775) | 128 (30.4) | 107 (23.9) | 7.35 (4.46) | 21.6 (15.4) | 10.1 (4.16) | 25.4 (16.7) | 13.0 (10.5) |
| Larynx | 1.49 (0.503) | 51.6 (4.34) | 115 (6.38) | 5.32 (1.07) | 12.6 (1.93) | 5.81 (0.668) | 13.6 (1.94) | 4.01 (0.949) |
| Oral cavity | 1.66 (0.321) | 75.9 (4.12) | 115 (4.03) | 8.96 (0.849) | 27.8 (1.86) | 11.1 (0.529) | 21.4 (1.85) | 9.24 (0.956) |
| Oropharynx | 6.10 (1.66) | 105 (12.2) | 142 (8.75) | 8.07 (2.48) | 48.3 (8.18) | 10.5 (1.72) | 64.0 (8.86) | 21.9 (5.44) |
| P‐value | .0002 | <.0001 | .13 | .16 | <.0001 | <.0001 | <.0001 | <.0001 |
| T factor | ||||||||
| T1‐2 | 2.75 (0.588) | 74.0 (5.36) | 113 (5.07) | 8.73 (1.09) | 32.7 (2.75) | 10.2 (0.689) | 29.8 (2.94) | 11.4 (1.51) |
| T3‐4 | 1.45 (0.260) | 73.8 (4.03) | 119 (4.12) | 7.58 (0.826) | 21.4 (1.80) | 9.69 (0.55) | 18.9 (1.84) | 7.68 (1.00) |
| P‐value | .03 | .97 | .38 | .39 | .0004 | .59 | .0009 | .03 |
| N factor | ||||||||
| Negative | 1.36 (0.261) | 63.7 (4.16) | 112 (4.60) | 7.44 (0.940) | 26.8 (2.43) | 8.86 (0.616) | 22.1 (2.34) | 8.65 (1.20) |
| Positive | 2.20 (0.450) | 75.7 (4.53) | 122 (4.57) | 8.40 (0.931) | 24.5 (2.09) | 10.7 (0.609) | 22.8 (2.30) | 8.70 (1.17) |
| P‐value | .13 | .06 | .11 | .47 | .49 | .04 | .84 | .98 |
| M factor | ||||||||
| M0 | 2.00 (0.291) | 73.4 (3.30) | 116 (3.23) | 8.09 (0.665) | 26.2 (1.59) | 9.79 (0.438) | 23.5 (1.65) | 9.23 (0.868) |
| M1 | 3.05E‐16 (2.21E‐16) | 70.7 (2.72) | 134 (15.3) | 1.47 (1.47) | 3.42 (2.22) | 6.23 (3.06) | 6.53 (2.79) | 1.06 (1.04) |
| P‐value | .50 | .94 | .57 | .32 | .15 | .42 | .31 | .35 |
| TNM stage | ||||||||
| I‐II | 1.85 (0.439) | 69.9 (6.86) | 111 (6.14) | 9.23 (1.48) | 33.5 (3.64) | 9.82 (0.961) | 27.8 (3.57) | 11.5 (2.00) |
| III‐IV | 2.01 (0.342) | 75.0 (3.67) | 118 (3.71) | 7.72 (0.738) | 23.9 (1.71) | 9.90 (0.480) | 22.1 (1.83) | 8.56 (0.943) |
| P‐value | .81 | .52 | .31 | .35 | .01 | .94 | .15 | .15 |
Abbreviations: HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; SE, standard error; TCM, central memory T cell; TEM, effector memory T cell; TN, naïve T cell; Tregs, regulatory T cells.