TABLE 4.
Correlation between markers with the cell‐of‐origin classification, Epstein–Barr virus‐encoded small RNA (EBER), and high‐grade B‐cell lymphoma (HGBCL)
| Marker | Cell‐of‐origin (Hans classifier) a | ||||
|---|---|---|---|---|---|
| P value | GCB | Non‐GCB | |||
| Mean | ±SD | Mean | ±SD | ||
| CD68 | .079 | 14.4 | 7.1 | 16.4 | 8.4 |
| CD16 | .00002 | 0.7 | 1.5 | 9.2 | 11.5 |
| MITF | .288 | 3.1 | 3.7 | 3.3 | 2.9 |
| CD163 | .003 | 19.2 | 19.9 | 30.6 | 19.6 |
| PTX3 | .026 | 4.7 | 11.8 | 18.4 | 20.7 |
| IL‐10 | .020 | 3.1 | 4.0 | 11.4 | 11.0 |
| FOXP3 | .645 | 1.8 | 2.6 | 2.2 | 2.9 |
| RGS1 | .126 | 6.6 | 6.6 | 15.2 | 14.8 |
| Marker | EBER | ||||
|---|---|---|---|---|---|
| P value | Positive | Negative | |||
| Mean | ±SD | Mean | ±SD | ||
| CD68 | .875 | 16.5 | 8.0 | 15.5 | 8.2 |
| CD16 | .362 | 6.6 | 10.5 | 7.1 | 10.8 |
| MITF | .482 | 3.5 | 3.0 | 3.1 | 3.2 |
| CD163 | .035 | 38.5 | 24.1 | 25.7 | 18.6 |
| PTX3 | .017 | 24.7 | 23.7 | 13.5 | 18.5 |
| IL‐10 | .160 | 5.8 | 7.5 | 9.3 | 10.8 |
| FOXP3 | .554 | 4.6 | 4.1 | 1.8 | 2.4 |
| RGS1 | .179 | 21.7 | 19.8 | 11.6 | 11.8 |
| Marker | HGBCL genotype by FISH | ||||
|---|---|---|---|---|---|
| P value | Positive | Negative | |||
| Mean | ±SD | Mean | ±SD | ||
| CD68 | .369 | 12.1 | 9.5 | 15.1 | 8.1 |
| CD16 | .890 | 2.1 | 9.8 | 2.1 | 2.3 |
| MITF | .748 | 2.1 | 2.5 | 3.1 | 2.8 |
| CD163 | .045 | 49.6 | 29.4 | 22.1 | 18.4 |
| PTX3 | .003 | 0.2 | 0.2 | 11.9 | 17.5 |
| IL‐10 | .464 | 4.1 | 3.6 | 8.8 | 10.2 |
| FOXP3 | .084 | 0.6 | 0.9 | 2.3 | 2.9 |
| RGS1 | .905 | 18.1 | 26.6 | 8.7 | 11 |
Abbreviations: GCB, germinal center B cell‐like; IL‐10, interleukin‐10; MITF, microphthalmia transcription factor; PTX3, pentraxin 3; RGS1, regulator of G‐protein signaling 1.
a
The same results were found when analyzing the diffuse large B‐cell lymphoma, not otherwise specified, only group.