TABLE 5.
Correlation between markers and outcome in patients with diffuse large B‐cell lymphoma
| Marker | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|
| P value | HR | 95% CI | P value | HR | 95% CI | |||
| Univariate analysis | ||||||||
| CD68 | .002 | 3.2 | 1.5 | 7.2 | .0001 | 4.4 | 1.9 | 10.0 |
| CD16 | .049 a | 1.5 | 0.9 | 2.6 | .022 | 2.0 | 1.1 | 3.5 |
| MITF | .020 | 1.9 | 1.1 | 3.2 | .249 | 1.4 | 0.8 | 2.5 |
| CD163 | .002 | 2.1 | 1.3 | 3.5 | .002 | 2.4 | 1.4 | 4.1 |
| PTX3 | .020 | 2.8 | 1.1 | 7.1 | .015 | 3.3 | 1.2 | 9.2 |
| IL‐10 | .017 | 2.4 | 1.1 | 5.0 | .016 | 2.6 | 1.2 | 5.9 |
| FOXP3 | .002 | 0.1 | 0.0 | 0.6 | .123 | 0.5 | 0.2 | 1.2 |
| Multivariate analysis b | ||||||||
| CD68 | .457 | 2.7 | 0.2 | 37.4 | .026 | 24.1 | 1.5 | 394.1 |
| CD16 | .604 | 0.7 | 0.2 | 2.8 | .536 | 0.7 | 0.2 | 2.4 |
| MITF | .386 | 1.8 | 0.5 | 6.5 | .94 | 1.0 | 0.3 | 3.2 |
| CD163 | .829 | 1.2 | 0.3 | 5.3 | .906 | 0.9 | 0.2 | 3.5 |
| PTX3 | .033 | 6.1 | 1.2 | 31.9 | .238 | 2.7 | 0.5 | 14.1 |
| IL‐10 | .287 | 2.1 | 0.5 | 8.0 | .269 | 2.1 | 0.6 | 7.6 |
| FOXP3 | .146 | 0.3 | 0.1 | 1.5 | .826 | 1.1 | 0.3 | 3.9 |
| IPI | .035 | 2.0 | 1.1 | 3.9 | .359 | 1.3 | 0.8 | 2.2 |
| Multivariate analysis c | ||||||||
| PTX3 | .020 | 4.5 | 1.3 | 18.2 | – | – | – | – |
| IL‐10 | .009 | 7.3 | 1.7 | 15.6 | .065 | 4 | 0.9 | 17.6 |
| FOXP3 | .111 | 0.3 | 0.1 | 1.3 | – | – | – | – |
| EBER | .023 | 4.8 | 4.8 | 1.2 | – | – | – | – |
| CD68 | – | – | – | – | .014 | 26.1 | 1.9 | 349 |
Abbreviations: –, no data; CI, confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression‐free survival.
a
Log‐rank (Mantel‐Cox) P = .136; Breslow (generalized Wilcoxon) P = .049.
b
Multivariate analysis, method = enter.
c
Multivariate analysis, Cox regression, method = backward conditional, predictors = CD68, CD16, microphthalmia transcription factor (MITF), CD163, pentraxin 3 (PTX3), interleukin‐10 (IL‐10), FOXP3, International Prognostic Index (IPI), cell‐of‐origin (Hans classifier), Epstein–Barr virus‐encoded small RNA (EBER), and high‐grade B‐cell lymphoma genotype.