Entezari 2015.
Study characteristics | ||
Methods | Double‐blinded placebo‐controlled clinical trial | |
Participants | Normotensive females Age: 18 to 30 years Setting: Shahid Beheshti University of Medical Sciences in Tehran, Iran |
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Interventions | Intervention: four capsules of supplementary calcium daily; each capsule contained 625 mg calcium carbonate, which is equal to 250 mg of calcium element. Control: 1000 mg dextrose capsules instead of calcium carbonate Trial duration: 1 month |
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Outcomes | Systolic and diastolic blood pressure in supine position after 10 min of rest | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not mentioned: "Eligible cases were randomly divided into two groups (treatment and control); treatment group received four capsules of supplementary calcium daily". |
Allocation concealment (selection bias) | Unclear risk | The method was not described |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | This double‐blinded placebo‐controlled clinical trial was carried out in normotensive females. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not mentioned |
Incomplete outcome data (attrition bias) All outcomes | High risk | 75 started; the authors did not mention how many in each group. More than "15 withdrew"; 22 in total (29.3%) finished "27 in calcium and 26 in control". |
Selective reporting (reporting bias) | Unclear risk | No protocol available |
Other bias | Low risk | This study was done in a population who were calcium deficient, and therefore the effect of calcium supplement should be shown more prominently. |