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. Author manuscript; available in PMC: 2023 Jan 15.
Published in final edited form as: J Mol Biol. 2021 Aug 28;434(1):167220. doi: 10.1016/j.jmb.2021.167220

Figure 2. Therapeutic strategies to enhance NIR activity.

Figure 2.

(A) One potential means by which NIR activity could be enhanced is through the use of small-molecule drugs. For example, a molecule that promotes the release of Ran-GTP (shown in teal) from NIRs in the nucleus would increase the pool of free NIRs available for binding to cargo (i). Alternatively, small molecule libraries or engineered compounds could be used to perform in vivo or in vitro screens for chaperone activity (ii). (B) Another approach could use a PROTAC-like molecule to direct NIRs to specified targets. (C) Finally, NIR activity could be augmented using genetic approaches to deliver saRNAs or ASOs to elevate NIR expression, or to deliver sequences via AAVs or lipid-containing nanoparticles to express NIRs directly.