Table 3.
Doppler ultrasound and Dynamic contrast-enhanced MRI measurements of placental function and oxygenation
| Parameter | Gestational day 85 | Gestational day 110 | Gestational day 135 | |||
|---|---|---|---|---|---|---|
| Control (n=4) |
Ethanol (n=4) |
Control (n=4) |
Ethanol (n=4) |
Control (n=4) |
Ethanol (n=4) |
|
| Uterine artery PI | 0.7±0.1 | 0.9±0.2 | 0.6±0.1 | 0.8±0.1 | 0.8±0.3 | 0.85±0.1 |
| Umbilical artery PI | 1.7±0.3 | 2.4±0.3* | 1.3±0.2 | 1.6±0.3 | 1.1±0.06 | 1.4±0.3 |
| cQuta (ml/min/kg) | 22.3±7.3 | 14±6.3 | 41±23 | 22±11.5* | 26.5±14 | 26±1.4 |
| cQuv | 17.7±2.2 | 9.8±3.6 | 24.6±4.8 | 15.1±0.7* | 31.5±7.1 | 28.9±13.7 |
| Total Placental blood flow (ml/min)§ | 289±120 | 121±27 | 681±39.6 | 285±142* | 559±190 | 414±221* |
Definition of abbreviations:
§
= obtained by DCE-MRI
PI = pulsatility index, VTI = velocity time integral
CSA (cross section of uterine artery) = π(diameter/2)2
Vmean (mean velocity) = 0.5 x maximum umbilical vein velocity
cQuta (uterine artery blood flow) = VTI x CSA x HR adjusted for maternal weight
cQuv (placental volume blood flow) = Vmean x CSA x 60
2-Way ANOVA used with post-hoc Tukey comparison test. Data are means ± SD.
*
p<0.05