Table 3:
Association of rs6742078 with testing for liver disorders
| Testing category | GG | GT | TT | P-value | OR [95%CI]* | P-value* | |
|---|---|---|---|---|---|---|---|
| Liver function tests1 | 8 [3,18] | 8 [3,18] | 7 [3,18] | 0.782 | 1.04 [0.79, 1.36] | 0.800 | |
| Hemolysis tests2 | 3264 (13.7%) | 2956 (13.6%) | 774 (14.1%) | 0.637 | 1.01 [0.97, 1.05] | 0.590 | |
| Viral hepatitis tests3 | 8170 (34.3%) | 7333 (33.7%) | 1956 (35.6%) | 0.029 | 1.01 [0.98, 1.04] | 0.576 | |
| Ultrasound4 | 3392 (14.2%) | 3133 (14.4%) | 855 (15.6%) | 0.04 | 1.04 [1.00, 1.08] | 0.033 | |
| Liver Biopsy | 808 (3.39%) | 703 (3.2%) | 196 (3.6%) | 0.400 | 1.00 [0.93, 1.08] | 0.973 |
1
alkaline phosphatase (AP), alanine transaminase (ALT), aspartate transaminase (AST), or gamma-glutamyl transferase (GGT);
2
haptoglobin, reticulocyte count;
3
hepatitis A, hepatitis B, hepatitis C;
4
abdominal ultrasound, liver ultrasound.
*
Adjusted by year of birth, sex, first five principal components and length of follow-up in the EHR.
See supplementary table S2 for complete list of tests and ICD and CPT codes for each category. For liver function tests the median (IQR) number of tests performed in each individual is shown; for all other tests the number of patients (percent) who had the test performed is shown.