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. 2021 Oct 18;78(2):259–265. doi: 10.1007/s00228-021-03232-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Geometric mean (± standard deviation) plasma concentration–time profiles for cannabichromene (CBC) in Spectrum Yellow oil on day 1 and day 7 for Treatment A: 120 mg CBD, 5.4 mg THC, and 6.6 mg CBC daily; Treatment B: 240 mg CBD, 10.8 mg THC, and 13.2 mg CBC daily; Treatment C: 360 mg CBD, 16.2 mg THC, and 19.8 mg CBC daily; and Treatment D: 480 mg CBD, 21.6 mg THC, and 26.4 mg CBC daily. Concentrations that were below the lower limit of quantification (0.78 ng/mL) were assigned as zero for analysis