Table 1.
Summary of plasma cannabichromene (CBC) concentrations (ng/mL) by treatment group
| Timepoint | Treatment Aa (n = 8) | Treatment Ba (n = 8) | Treatment Ca (n = 8) | Treatment Da (n = 8) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n BLoQ (n) | Mean (SD, CV [%]) | n BLoQ (n) | Mean (SD, CV [%]) | n BLoQ (n) | Mean (SD, CV [%]) | n BLoQ (n) | Mean (SD, CV [%]) | ||||
| Day 1 | |||||||||||
| Predose | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 8 (8) | 0 (0) | |||
| 1 h | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 4 (8) | 1.51 (1.90, 125.83) | |||
| 2 h | 7 (8) | 0.27 (0.76, 281.48) | 2 (8) | 2.83 (3.48, 122.97) | 5 (8) | 1.43 (2.07, 144.76) | 4 (8) | 4.00 (4.44, 111.00) | |||
| 4 h | 6 (8) | 0.69 (1.39, 201.45) | 5 (8) | 1.46 (2.37, 162.33) | 3 (8) | 2.86 (2.06, 72.03) | 2 (8) | 3.33 (2.95, 40.24) | |||
| 6 h | 8 (8) | 0 (0) | 7 (8) | 0.27 (0.78, 288.89) | 6 (8) | 1.00 (1.94, 194.00) | 5 (8) | 1.34 (2.24, 167.16) | |||
| 8 h | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 7 (8) | 0.22 (0.62, 281.82) | 7 (8) | 0.35 (0.98, 280.00) | |||
| 12 h | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 7 (8) | 1.09 (3.07, 284.65) | |||
| Day 7 | |||||||||||
| Predose | 7 (7) | 0 (0) | 8 (8) | 0 (0) | 7 (8) | 0.22 (0.62, 281.82) | 6 (8) | 0.49 (0.92, 187.76) | |||
| 1 h | 5 (7) | 0.69 (1.22, 176.81) | 6 (8) | 1.31 (2.75, 209.92) | 7 (8) | 0.36 (1.02, 283.33) | 3 (8) | 2.04 (2.22, 108.82) | |||
| 2 h | 6 (7) | 0.38 (1.01, 265.79) | 3 (8) | 3.76 (5.41, 143.88) | 4 (8) | 3.03 (4.30, 141.91) | 2 (8) | 4.91 (4.47, 91.039) | |||
| 4 h | 7 (7) | 0 (0) | 2 (8) | 2.44 (1.71, 70.08) | 0 (8) | 4.02 (1.66, 41.29) | 1 (8) | 4.47 (4.19, 93.74) | |||
| 6 h | 7 (7) | 0 (0) | 7 (8) | 0.22 (0.63, 286.36) | 4 (8) | 1.59 (1.86, 116.98) | 4 (8) | 3.18 (5.56, 174.84) | |||
| 8 h | 7 (7) | 0 (0) | 8 (8) | 0 (0) | 5 (8) | 0.78 (1.09, 1.67) | 5 (8) | 1.67 (2.65, 158.68) | |||
| 12 h | 7 (7) | 0 (0) | 8 (8) | 0 (0) | 8 (8) | 0 (0) | 5 (8) | 1.00 (1.43, 143.00) | |||
Timepoints are in relation to the morning dose. Concentrations that were below the lower limit of quantification were assigned as zero for analysis. n number, BLoQ below limit of quantification; lower limit of quantification of cannabichromene (CBC) is 0.78 ng/mL, CV coefficient of variation, SD standard deviation
aTreatment A: 120 mg CBD, 5.4 mg THC, and 6.6 mg CBC daily; Treatment B: 240 mg CBD, 10.8 mg THC, and 13.2 mg CBC daily; Treatment C: 360 mg CBD, 16.2 mg THC, and 19.8 mg CBC daily; and Treatment D: 480 mg CBD, 21.6 mg THC, and 26.4 mg CBC daily