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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2021 Nov 6;212:173294. doi: 10.1016/j.pbb.2021.173294

Fig. 1. Hippocampal participation in addictive disease circuitry.

Fig. 1.

The hippocampus plays a significant role in the learning aspect of addictive diseases. Associative learning enhances the classical dopamine reward system which is important for transitioning from initial drug use to abuse/dependence. Hipp - hippocampus; PFC - prefrontal cortex; NAc - nucleus accumbens; VTA - ventral tegmental area; Amyg - amygdala.