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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2021 Nov 6;212:173294. doi: 10.1016/j.pbb.2021.173294

Fig. 14: Opioid receptors redistribute following CIS in a manner that would promote oxycodone associative learning in female rats but not males.

Fig. 14:

In CA3 pyramidal cells, total and cytoplasmic DORs were elevated in CIS Sal females. Following Oxy CPP, DORs had a similar distribution in CIS females. Moreover, the number of DORs mossy fiber CA3 synapses in CIS Sal females was similar to that observed in females in elevated estrogen states suggesting that mechanisms that promote DOR-mediated LTP are in place following CIS. In DG, CIS Oxy-females had greater numbers of MORs and DORs in interneurons suggesting mechanisms for enhanced disinhibition are still in place. In contrast, CIS results in few distribution changes in Sal- and Oxy males, which may contribute to the reduced ability of males to acquire Oxy-CPP. (−): indicates disinhibition; (+): indicates activation. Arrows indicate direction of change. Results from Reich et al 2019.