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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2021 Nov 6;212:173294. doi: 10.1016/j.pbb.2021.173294

Fig. 15: Redistribution of opioid receptors following acute THC may differentially affect opioid-associated plasticity in female and male rats.

Fig. 15:

Following acute THC, DORs are trafficked to different regions of CA3 dendrites in females and males suggesting sex-specific mechanisms for increased opioid-mediated synaptic plasticity. In GABAergic PARV interneurons, MORs are internalized in males which would leading to decreased disinhibition, thus suggesting that acute THC would reduce opioid-mediated learning processes in males. (−): indicates disinhibition; (+): indicates activation. Arrows indicate direction of change. Results from Windisch and Mazid et al 2021