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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2021 Nov 6;212:173294. doi: 10.1016/j.pbb.2021.173294

Fig. 4. Schematic of a granule cell and associated interneuron interactions in the dentate gyrus.

Fig. 4.

Mu opioid receptors (MORs; blue) are found on inhibitory GABAergic PARV-interneurons that project to the somata and proximal dendrites of granule cells. Activation of MORs lead to a disinhibition and subsequent activation of the granule cells. Delta opioid receptors (DORs; orange) are found on neuropeptide Y/somatostatin (NPY/SOM) interneurons that contain primarily project to the distal dendrites of granule cells. Kappa opioid receptors (KORs; pink) are primarily found in substance P (subP; pink) afferents that arise from the hypothalamus. LEnk (green) is found in granule cells and in the LPP.