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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Biochem Behav. 2021 Nov 6;212:173294. doi: 10.1016/j.pbb.2021.173294

Fig. 9. Following CIS opioid receptors are redistributed in a manner may promote opioid-associated learning in female rats and cause structural changes in males.

Fig. 9.

Schematic of CA3 pyramidal cell shows males have significant adverse dendritic retractions following CIS subsequently reducing the possibility of opioid mediated synaptic plasticity, Furthermore, males have decreased plasmalemma DORs in CA3 pyramidal cell dendrites thus, further reducing the opioid-mediated plasticity. In the DG, males also have reduced numbers of basket cells (know to contain MORs) following CIS. Conversely, the schematic of the DG granule cell shows that DORs increase near the plasmalemma of GABAergic NPY-interneurons in females, enhancing disinhibition leading to opioid-mediated excitation. Moreover, females have elevated total levels of MORs in basket cells. (−): indicates disinhibition; (+): indicates activation. Arrows indicate direction of change.