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. 2022 Jan 10;12:344. doi: 10.1038/s41598-021-04341-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased serum miR-92a level in patients with hypertension. (A) qPCR analysis of serum miR-92a level in patients with hypertension (HTN) (n = 44) and healthy controls (HC) (n = 21). Cel-miR-39 was used as a spike-in control. The data are fold change normalized to the averaged level of HCs. (B) Brachial–ankle pulse wave velocity (baPWV) of patients and controls. (C, D) Serum NO and ET-1 levels. (E–I) Correlations between serum miR-92a level and baPWV (E), SBP (F), DBP (G) serum ET-1 (H) and NO (I). (J, K) Correlation between baPWV and serum NO (J) and ET-1 (K) levels. Data are mean ± SEM. Normally distributed data were analyzed by the two-tailed Student t test (C, D), and the two-tailed Student t test with Welch correction (B) between 2 indicated groups. Non-normally distributed data were analyzed by the Mann–Whitney U test (A) between 2 indicated groups. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001. r_s Spearman correlation coefficient.