Fig. 4. Intravenous administration of MDL28170 (3 mg/kg. b. w.) ameliorated burn injury-induced heart damage.

A The plasma levels of LDH and cTnI, caspase-3 in heart tissue, and representative blots showing PARP-1 with densitometric analysis. GAPDH served as a loading control. B Representative left ventricular pressure tracings and the results of heart function and mean arterial blood pressure (MAP). Each independent data with the mean is presented. n = 6 rats in each group. Western blotting was performed in six independent biological experiments, and there were three technical replicates per sample. ^##P < 0.01 vs. the sham group. *P < 0.05, **P < 0.01 vs. the burn group. M + Sham and M + Burn refer to the sham-operated and burn-treated rats that received MDL28170, respectively.