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. 2022 Jan 10;8:10. doi: 10.1038/s41420-021-00810-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative blots and densitometric analysis showing siRNA-mediated knockdown of CAPN1 and the proteolysis of α-spectrin. B Blockade of CAPN1 with siRNA improved cell viability and reduced caspase-3 activity and PARP-1 degradation. GAPDH served as a loading control. Each independent data with the mean is presented. n = 6. Western blotting was performed in six independent biological experiments, and there were three technical replicates per sample. ^##, **P < 0.01.