Table 1.
Demographic and clinical characteristics of unmedicated first-episode MDD and healthy controls.
| Characteristics | HC Male (N = 106) | HC Female (N = 137) | MDD Male (N = 48) | MDD Female (N = 76) | Diagnosis | Sex | Diagnosis × Sex | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | F | P | F/t | P | F | P | |
| Age (Years) | 20.54 | 2.13 | 21.33 | 4.28 | 24.75 | 5.16 | 25.68 | 7.90 | 59.07 | <0.001 | 2.39 | 0.120 | 0.02 | 0.898 |
| Education (Years) | 14.20 | 1.25 | 14.48 | 1.61 | 14.56 | 1.97 | 14.03 | 2.32 | 0.05 | 0.827 | 0.40 | 0.530 | 4.31 | 0.039 |
| Mean FD | 0.10 | 0.04 | 0.12 | 0.05 | 0.10 | 0.08 | 0.12 | 0.06 | 1.34 | 0.249 | 6.15 | 0.014 | 0.04 | 0.846 |
| Illness duration (Months) | 8.32 | 9.41 | 8.07 | 9.98 | – | – | −0.11 | 0.910 | – | – | ||||
| HAMD | – | – | – | – | 20.35 | 6.02 | 22.49 | 4.69 | – | – | −2.21 | 0.029 | – | – |
| BDI-II | 5.53 | 6.04 | 5.26 | 4.89 | 27.10 | 10.39 | 29.65 | 9.88 | 776.53 | <0.001 | 1.91 | 0.168 | 2.93 | 0.088 |
| Cognitive | 1.82 | 2.13 | 1.85 | 1.90 | 8.27 | 3.99 | 9.19 | 3.85 | 482.30 | <0.001 | 2.28 | 0.132 | 2.00 | 0.159 |
| Affective & Somatic | 2.30 | 2.88 | 1.83 | 2.09 | 11.15 | 4.92 | 12.57 | 4.01 | 721.02 | <0.001 | 1.70 | 0.19 | 6.79 | 0.010 |
| STAI-S | 37.02 | 9.08 | 37.98 | 7.99 | 57.47 | 13.64 | 58.42 | 10.67 | 345.47 | <0.001 | 0.76 | 0.386 | <0.001 | 0.996 |
FD framewise displacement, HAMD 17 item Hamilton depression rating scale, BDI-II Beck depression inventory, STAI state and trait anxiety inventory, HC healthy controls, MDD major depressive disorder.