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. 2022 Jan 10;8:12. doi: 10.1038/s41420-021-00801-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Human renal proximal tubular (HK-2) cells were treated with 20 μM cisplatin in the absence or presence of canagliflozin (CANA) at the indicated concentrations for 24 h. A Cell viability was evaluated via CCK-8 assay. Data are expressed as mean ± SD (N = 4). Differences between groups were evaluated using one-way ANOVA followed by Bonferroni’s multiple comparison test. **P < 0.01, ***P < 0.001, significantly different from the cisplatin-only treated group. B Representative immunoblot analysis. C–E Densitometric analysis of immunoblots to estimate the relative abundance of indicated molecules as normalized to that of β-actin. Data are expressed as mean ± SD (N = 3). Differences between groups were evaluated using one-way ANOVA followed by Bonferroni’s multiple comparison test. ***P < 0.001, significantly different from the cisplatin-only treated group.