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. 2022 Jan 10;12:12. doi: 10.1038/s41398-021-01712-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Volcano plot of all 19175 genes; significantly (p < 0.05) differentially expressed genes (fold change > or <1.3) are indicated in red (upregulated), or blue (downregulated). Gene names are indicated for the top 25 differentially expressed protein-coding genes. b Pathways enriched in TRD vs. HC subjects (red = positive z-score, blue = negative z-score) identified by Ingenuity Pathway Analyzer (IPA). c 5 most significant gene ontology (GO) terms for upregulated genes enriched in TRD vs. HC. No significant GO terms in downregulated genes. d Genes enriched in Interferon signaling pathway combined from both IPA and GO (red indicates upregulated in TRD vs. HC). e Predicted upstream regulators using IPA (red = predicted activation, blue = predicted inhibition).