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. 2022 Jan 10;12:12. doi: 10.1038/s41398-021-01712-0

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© The Author(s) 2021

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Fig. 2 — a Volcano plots showing significantly (p < 0.05, fold change > or <1.3) differentially expressed genes (DEG) [red = upregulated and blue = downregulated]. Gene names are indicated for the top 25 differentially expressed protein-coding genes. b Ingenuity Pathway Analysis (IPA) identified two biological pathways (red = activation) enriched at baseline in responders vs. non-responders. c DEGs within each pathway. d Predicted upstream regulators identified by IPA (red indicates predicted activation, blue indicates predicted inhibition).