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. 2022 Jan 10;12:12. doi: 10.1038/s41398-021-01712-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Volcano plot showing the top 25 protein-coding genes associated with ketamine treatment response. Positive regression coefficient (red) indicates decreased gene expression with clinical improvements (i.e., higher delta MADRS), negative regression coefficient (blue) indicates that clinical improvement is associated with increased gene expression. b Ingenuity Pathway Analyzer (IPA) identified several pathways associated with ketamine treatment response (red = positive z-score)). c Genes enriched in the top two pathways (red = positive regression coefficient, blue = negative regression coefficient). d Predicted upstream regulators using Ingenuity Pathway Analysis (red = predicted activation).