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. 2022 Jan 10;8:17. doi: 10.1038/s41420-021-00794-5

Fig. 2. miR-142-5p downregulation is linked to radioresistance of NPC cells and poor prognosis of NPC patients.

Fig. 2

A The schematic diagram of constructing a cell model (5-8FR and CNE-3R) of radioresistance on human NPC cell lines 5–8 F and CNE-3. B The survival rate of cells at different doses of radiation. C The protein levels of cle-PARP and cle-caspase3 were detected by western blot after constructing a cell model (5-8FR and CNE-3R) of radioresistance. D RT-qPCR to measure the miR-142-5p levels in 5–8 F and CNE-3 cells, and 5-8FR and CNE-3R cells. E The level of miR-142-5p in peripheral blood of radiosensitive patients (n = 30) and radiotherapy-resistant NPC patients (n = 45) determined by RT-qPCR. F Kaplan–Meier method to analyze the relationship of miR-142-5p expression in peripheral blood and overall survival of NPC patients with radioresistance. *p < 0.05. All experiments were repeated three times.