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. 2022 Jan 10;8:17. doi: 10.1038/s41420-021-00794-5

Fig. 4. EVs-miR-142-5p facilitates NPC cell radiosensitivity to repress proliferation and increase apoptosis of NPC cells.

Fig. 4

A The expression of miR-142-5p in EVs secreted by 5–8 F and CNE-3 cells assessed by RT-qPCR. B RT-qPCR to check the expression of miR-142-5p in 5-8FR and CNE-3R cells after co-incubation with the EVs secreted by 5–8 F and CNE-3 cells. C Colony formation assay to detect the number of colonies formed by 5-8FR and CNE-3R cells under different doses of radiotherapy. D The effect of EVs-miR-142-5p on the expression of γH2AX protein in 5-8FR and CNE-3R cells detected by immunofluorescence staining. E Western blot to detect the effect of EVs-miR-142-5p on the expression of γH2AX protein in 5-8FR and CNE-3R cells. F MTS to determine the effect of EVs-miR-142-5p on the proliferation of 5-8FR and CNE-3R cells. G The effect of EVs-miR-142-5p on the apoptosis rate of 5-8FR and CNE-3R cells detected by flow cytometry. H Western blot to appraise the expression of apoptotic proteins in 5-8FR and CNE-3R cells with EVs-miR-142-5p. *p < 0.05. All experiments were repeated three times.