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. 2022 Jan 10;8:17. doi: 10.1038/s41420-021-00794-5

Fig. 7. EVs-miR-142-5p could enhance the radiosensitivity of 5-8FR cells in nude mice by disrupting HGF/c-Met and EGF/EGFR pathways.

Fig. 7

A Naked eye observation of xenograft tumor in nude mice of each group after 20 days of 6 Gy radiotherapy. B Changes of xenograft tumor volume in nude mice of each group. C Weight changes of xenograft tumor in nude mice. D Representative images of H&E staining and TUNEL staining of tumors of nude mice (scale bars: 50 μm [left panel] as well as quantification of TUNEL positive cells [right panel]). E, The expression of miR-142-5p detected by RT-qPCR. F The protein expression of p-c-Met and p-EGFR detected by Western blot. *p < 0.05 vs. control mice; #p < 0.05 vs. X-IR-treated mice; &p < 0.05 vs. mice treated with EVs-miR-142-5p + X-IR. There were ten nude mice in each group.